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Advances in Molecular Genetics, Genomics, Proteomics, Metabolomics, and Systems Biology

MicroRNAs in Cardiovascular Biology and Heart Disease

Daniele Catalucci, PhD; Paolo Gallo, MD and Gianluigi Condorelli, MD, PhD

From the Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Multimedica (D.C., G.C.), Milan, Italy; Department of Cardiovascular Medicine and Fondazione San Raffaele (P.G.), Campus BioMedico University, Rome, Italy; and Division of Cardiology (G.C.), Department of Medicine, University of California San Diego, La Jolla, Calif.

Correspondence to Gianluigi Condorelli, MD, PhD, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Multimedica, Via Gaudenzio Fantoli 16/15, 20138 Milan, Italy. E-mail gcondorelli{at}ucsd.edu

MicroRNAs play important roles in many cellular and biological functions via the regulation of mRNA target translation. In the cardiovascular field, microRNAs are now acknowledged as fundamental in regulating the expression of genes that governs physiological and pathological myocardial adaptation to stress. Here, we review recent progress in the understanding of microRNA functions and their involvement in heart disease.

Key Words: cardiovascular diseases • genes • myocardium • microRNA • heart failure • cardiac hypertrophy • antagomirs