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Book Reviews

Cardiovascular Genetics and Genomics for the Cardiologist

Ramachandran S. Vasan, MD

National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Mass, Cardiology Section and Department of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Mass

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Introduction

 
Victor J. Dzau, Choong-Chin Liew, eds.
308 pp., illustrated. Malden, Mass: Blackwell Futura; 2007. $144.95. ISBN 978–1-4051–3394-4.

Given the rapidly growing knowledge in the field of genetics and genomics and the furious pace of translational research, the average cardiologist today is faced with information overload and a discipline that is changing in fundamental ways. The challenges are further magnified by the fact that training curricula for cardiologists have not yet bridged the gap between conventional practice of cardiovascular medicine and the futuristic trends in the discipline. In this context, this book fills a unique void, and is a must read for cardiologists, including fellows and faculty.

The book is organized into three parts preceded by an introductory chapter. The introductory chapter provides an overview of the history of gene in the twentieth and twenty-first centuries and contains a very basic primer on genetics and genomics. The text traces a course from monogenic disorders to multifactorial disease to the role of genetics in therapy of cardiovascular disease. The first part consists of 4 chapters that discuss monogenic cardiovascular disease: hypertrophic and dilated cardiomyopathies, hypercholesterolemia and the long QT syndrome. The second part focuses on polygenic disorders, and includes 3 chapters: atherosclerosis, heart failure and hypertension. The third and final part comprises of chapters on gene therapy, stem cell therapy, pharmacogenetics and blood-based gene profiling. The presentation style of each chapter is attractive, the language clear, the content concise, the figure and tables are well organized, and the bibliography adequate. The molecular . . . [Full Text of this Article]