Epidemiology, Lifestyle, and Prevention

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Chasing—and Catching—the Wild GooseHypothesis-Free Post-Hoc Stratification Studies as a New Paradigm for Drug Development
Klaus Lindpaintner

Circulation: Cardiovascular Genetics. 2015;8:253-255, originally published April 21, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001037

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Deciphering Unexplained Familial DyslipidemiasDo We Have the Tools?
Heribert Schunkert and Felix Bourier

Circulation: Cardiovascular Genetics. 2015;8:250-252, originally published April 21, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001066

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Systems Biology With High-Throughput Sequencing Reveals Genetic Mechanisms Underlying the Metabolic Syndrome in the Lyon Hypertensive RatCLINICAL PERSPECTIVE
Jinkai Wang, Man Chun John Ma, Amanda K. Mennie, Janette M. Pettus, Yang Xu, Lan Lin, Matthew G. Traxler, Jessica Jakoubek, Santosh S. Atanur, Timothy J. Aitman, Yi Xing and Anne E. Kwitek

Circulation: Cardiovascular Genetics. 2015;8:316-326, originally published January 8, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000520

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DNA Methylation of Lipid-Related Genes Affects Blood Lipid LevelsCLINICAL PERSPECTIVE
Liliane Pfeiffer, Simone Wahl, Luke C. Pilling, Eva Reischl, Johanna K. Sandling, Sonja Kunze, Lesca M. Holdt, Anja Kretschmer, Katharina Schramm, Jerzy Adamski, Norman Klopp, Thomas Illig, Åsa K. Hedman, Michael Roden, Dena G. Hernandez, Andrew B. Singleton, Wolfgang E. Thasler, Harald Grallert, Christian Gieger, Christian Herder, Daniel Teupser, Christa Meisinger, Timothy D. Spector, Florian Kronenberg, Holger Prokisch, David Melzer, Annette Peters, Panos Deloukas, Luigi Ferrucci and Melanie Waldenberger

Circulation: Cardiovascular Genetics. 2015;8:334-342, originally published January 12, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000804

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Serum Lipid Levels, Body Mass Index, and Their Role in Coronary Artery CalcificationCLINICAL PERSPECTIVEA Polygenic Analysis
Jessica van Setten, Ivana Išgum, Sonali Pechlivanis, Vinicius Tragante, Pim A. de Jong, Joanna Smolonska, Mathieu Platteel, Per Hoffmann, Matthijs Oudkerk, Harry J. de Koning, Markus M. Nöthen, Susanne Moebus, Raimund Erbel, Karl-Heinz Jöckel, Max A. Viergever, Willem P.Th.M. Mali and Paul I.W. de Bakker

Circulation: Cardiovascular Genetics. 2015;8:327-333, originally published January 10, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000496

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Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes MellitusCLINICAL PERSPECTIVE
Francesco Paneni, Sarah Costantino, Rodolfo Battista, Lorenzo Castello, Giuliana Capretti, Sergio Chiandotto, Giuseppe Scavone, Angelo Villano, Dario Pitocco, Gaetano Lanza, Massimo Volpe, Thomas F. Lüscher and Francesco Cosentino

Circulation: Cardiovascular Genetics. 2015;8:150-158, originally published December 3, 2014
https://doi.org/10.1161/CIRCGENETICS.114.000671

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Pro12Ala Polymorphism of the PPARγ2 Gene Interacts With a Mediterranean Diet to Prevent Telomere Shortening in the PREDIMED-NAVARRA Randomized TrialCLINICAL PERSPECTIVE
Sonia García-Calzón, Miguel A. Martínez-González, Cristina Razquin, Dolores Corella, Jordi Salas-Salvadó, J. Alfredo Martínez, Guillermo Zalba and Amelia Marti

Circulation: Cardiovascular Genetics. 2015;8:91-99, originally published November 18, 2014
https://doi.org/10.1161/CIRCGENETICS.114.000635

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Common Low-Density Lipoprotein Receptor p.G116S Variant Has a Large Effect on Plasma Low-Density Lipoprotein Cholesterol in Circumpolar Inuit PopulationsCLINICAL PERSPECTIVE
Joseph B. Dubé, Jian Wang, Henian Cao, Adam D. McIntyre, Christopher T. Johansen, Scarlett E. Hopkins, Randa Stringer, Siyavash Hosseinzadeh, Brooke A. Kennedy, Matthew R. Ban, T. Kue Young, Philip W. Connelly, Eric Dewailly, Peter Bjerregaard, Bert B. Boyer and Robert A. Hegele

Circulation: Cardiovascular Genetics. 2015;8:100-105, originally published November 20, 2014
https://doi.org/10.1161/CIRCGENETICS.114.000646

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Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in WhitesCLINICAL PERSPECTIVE
Naveen L. Pereira, Nirubol Tosakulwong, Christopher G. Scott, Gregory D. Jenkins, Naresh Prodduturi, Yubo Chai, Timothy M. Olson, Richard J. Rodeheffer, Margaret M. Redfield, Richard M. Weinshilboum and John C. Burnett

Circulation: Cardiovascular Genetics. 2015;8:141-149, originally published December 1, 2014
https://doi.org/10.1161/CIRCGENETICS.114.000624

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Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes
Steven C. Hunt, Jeremy D. Kark and Abraham Aviv

Circulation: Cardiovascular Genetics. 2015;8:4-7, originally published February 17, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000964

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