Heart Failure and Cardiac Disease

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Unraveling De Novo Copy Number Variants in Congenital Heart DefectsThe Bottom of the Iceberg Is Under Attack
Patrice Bouvagnet

Circulation: Cardiovascular Genetics. 2016;9:4-5, originally published February 16, 2016
https://doi.org/10.1161/CIRCGENETICS.116.001360

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Application of Genetic Testing in Hypertrophic Cardiomyopathy for Preclinical Disease Detection
Jodie Ingles, Charlotte Burns, Alexandra Barratt and Christopher Semsarian

Circulation: Cardiovascular Genetics. 2015;8:852-859, originally published December 15, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001093

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Green Tea Catechin Normalizes the Enhanced Ca²⁺ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy–Associated Mutation in Human Cardiac Troponin I (K206I)CLINICAL PERSPECTIVE
Chad M. Warren, Chehade N. Karam, Beata M. Wolska, Tomoyoshi Kobayashi, Pieter P. de Tombe, Grace M. Arteaga, J. Martijn Bos, Michael J. Ackerman and R. John Solaro

Circulation: Cardiovascular Genetics. 2015;8:765-773, originally published November 9, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001234

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Eya4 Induces Hypertrophy via Regulation of p27^kip1CLINICAL PERSPECTIVE
Tatjana Williams, Moritz Hundertmark, Peter Nordbeck, Sabine Voll, Paula Anahi Arias-Loza, Daniel Oppelt, Melanie Mühlfelder, Susanna Schraut, Ines Elsner, Martin Czolbe, Lea Seidlmayer, Britta Heinze, Stefanie Hahner, Katrin Heinze, Jost Schönberger, Peter Jakob and Oliver Ritter

Circulation: Cardiovascular Genetics. 2015;8:752-764, originally published October 23, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001134

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Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve DiseaseCLINICAL PERSPECTIVE
Sandra Guauque-Olarte, David Messika-Zeitoun, Arnaud Droit, Maxime Lamontagne, Joël Tremblay-Marchand, Emilie Lavoie-Charland, Nathalie Gaudreault, Benoit J. Arsenault, Marie-Pierre Dubé, Jean-Claude Tardif, Simon C. Body, Jonathan G. Seidman, Catherine Boileau, Patrick Mathieu, Philippe Pibarot and Yohan Bossé

Circulation: Cardiovascular Genetics. 2015;8:812-822, originally published November 9, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001145

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Cardiac Disease Status Dictates Functional mRNA Targeting Profiles of Individual MicroRNAsCLINICAL PERSPECTIVE
Scot J. Matkovich, Gerald W. Dorn, Tiffani C. Grossenheider and Peter A. Hecker

Circulation: Cardiovascular Genetics. 2015;8:774-784, originally published November 9, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001237

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ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart FailureCLINICAL PERSPECTIVE
Byambajav Buyandelger, Catherine Mansfield, Sawa Kostin, Onjee Choi, Angharad M. Roberts, James S. Ware, Francesco Mazzarotto, Francesco Pesce, Rachel Buchan, Rivka L. Isaacson, Josée Vouffo, Sylvia Gunkel, Gudrun Knöll, Sara J. McSweeney, Heming Wei, Andreas Perrot, Conny Pfeiffer, Mohammad Reza Toliat, Kristina Ilieva, Ewelina Krysztofinska, Marina M. López-Olañeta, Jesús M. Gómez-Salinero, Albrecht Schmidt, Keat-Eng Ng, Niels Teucher, Ju Chen, Martin Teichmann, Martin Eilers, Wilhelm Haverkamp, Vera Regitz-Zagrosek, Gerd Hasenfuss, Thomas Braun, Dudley J. Pennell, Ian Gould, Paul J.R. Barton, Enrique Lara-Pezzi, Sebastian Schäfer, Norbert Hübner, Leanne E. Felkin, Declan P. O’Regan, Thomas Brand, Hendrik Milting, Peter Nürnberg, Michael D. Schneider, Sanjay Prasad, Enrico Petretto and Ralph Knöll

Circulation: Cardiovascular Genetics. 2015;8:643-652, originally published July 14, 2015
https://doi.org/10.1161/CIRCGENETICS.113.000690

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Enhanced Classification of Brugada Syndrome–Associated and Long-QT Syndrome–Associated Genetic Variants in the SCN5A-Encoded Na_v1.5 Cardiac Sodium ChannelCLINICAL PERSPECTIVE
Jamie D. Kapplinger, John R. Giudicessi, Dan Ye, David J. Tester, Thomas E. Callis, Carmen R. Valdivia, Jonathan C. Makielski, Arthur A. Wilde and Michael J. Ackerman

Circulation: Cardiovascular Genetics. 2015;8:582-595, originally published April 22, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000831

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Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family MembersCLINICAL PERSPECTIVE
Judith A. Groeneweg, Aditya Bhonsale, Cynthia A. James, Anneline S. te Riele, Dennis Dooijes, Crystal Tichnell, Brittney Murray, Ans C.P. Wiesfeld, Abhishek C. Sawant, Bina Kassamali, Douwe E. Atsma, Paul G. Volders, Natasja M. de Groot, Karin de Boer, Stefan L. Zimmerman, Ihab R. Kamel, Jeroen F. van der Heijden, Stuart D. Russell, Maarten Jan Cramer, Ryan J. Tedford, Pieter A. Doevendans, Toon A. van Veen, Harikrishna Tandri, Arthur A. Wilde, Daniel P. Judge, J. Peter van Tintelen, Richard N. Hauer and Hugh Calkins

Circulation: Cardiovascular Genetics. 2015;8:437-446, originally published March 27, 2015
https://doi.org/10.1161/CIRCGENETICS.114.001003

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Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve DiseaseCLINICAL PERSPECTIVE
Nassir M. Thalji, Michael A. Hagler, Heyu Zhang, Grace Casaclang-Verzosa, Asha A. Nair, Rakesh M. Suri and Jordan D. Miller

Circulation: Cardiovascular Genetics. 2015;8:516-528, originally published March 26, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000921

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