Pharmacology

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Is Plasma Renin Activity Genetically Determined and How Much Does It Matter for Treating Hypertension?
Francois Alhenc-Gelas and Joel Menard

Circ Genom Precis Med. 2018;11:e002139, originally published April 12, 2018
https://doi.org/10.1161/CIRCGEN.118.002139

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Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses)
Caitrin W. McDonough, Oyunbileg Magvanjav, Ana C.C. Sá, Nihal M. El Rouby, Chintan Dave, Amelia N. Deitchman, Marina Kawaguchi-Suzuki, Wenbin Mei, Yong Shen, Ravi Shankar Prasad Singh, Mohamed Solayman, Kent R. Bailey, Eric Boerwinkle, Arlene B. Chapman, John G. Gums, Amy Webb, Steven E. Scherer, Wolfgang Sadee, Stephen T. Turner, Rhonda M. Cooper-DeHoff, Yan Gong and Julie A. Johnson

Circ Genom Precis Med. 2018;11:e001854, originally published April 12, 2018
https://doi.org/10.1161/CIRCGEN.117.001854

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Clinical Outcomes and Sustainability of Using CYP2C19 Genotype–Guided Antiplatelet Therapy After Percutaneous Coronary Intervention
Craig R. Lee, Vindhya B. Sriramoju, Alexandra Cervantes, Lucius A. Howell, Nicholas Varunok, Shivanshu Madan, Kasey Hamrick, Melissa J. Polasek, John Andrew Lee, Megan Clarke, Jonathan D. Cicci, Karen E. Weck and George A. Stouffer

Circ Genom Precis Med. 2018;11:e002069, originally published April 3, 2018
https://doi.org/10.1161/CIRCGEN.117.002069

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Implementation of Genotype-Guided Antiplatelet TherapyFeasible but Not Without Obstacles
Joshua P. Lewis

Circ Genom Precis Med. 2018;11:e002118, originally published April 3, 2018
https://doi.org/10.1161/CIRCGEN.118.002118

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Statin Effects on Metabolic ProfilesCLINICAL PERSPECTIVEData From the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial)
Daniel Kofink, Ruben N. Eppinga, Wiek H. van Gilst, Stephan J.L. Bakker, Robin P.F. Dullaart, Pim van der Harst and Folkert W. Asselbergs

Circulation: Genomic and Precision Medicine. 2017;10:e001759, originally published December 13, 2017
https://doi.org/10.1161/CIRCGENETICS.117.001759

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Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and InflammationCLINICAL PERSPECTIVEConcordance With Clinical Outcomes
Jean-Claude Tardif, David Rhainds, Mathieu Brodeur, Yassamin Feroz Zada, René Fouodjio, Sylvie Provost, Marie Boulé, Sonia Alem, Jean C. Grégoire, Philippe L. L’Allier, Reda Ibrahim, Marie-Claude Guertin, Ian Mongrain, Anders G. Olsson, Gregory G. Schwartz, Eric Rhéaume and Marie-Pierre Dubé

Circulation: Genomic and Precision Medicine. 2016;9:340-348, originally published July 14, 2016
https://doi.org/10.1161/CIRCGENETICS.116.001405

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So Far, PCSK9 Inhibitors Work for All Heterozygous FH Patients
Markey C. McNutt and Zahid Ahmad

Circulation: Genomic and Precision Medicine. 2015;8:749-751, originally published December 15, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001256

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Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal AntibodyCLINICAL PERSPECTIVE
Paul N. Hopkins, Joep Defesche, Sigrid W. Fouchier, Eric Bruckert, Gérald Luc, Bertrand Cariou, Barbara Sjouke, Trond P. Leren, Mariko Harada-Shiba, Hiroshi Mabuchi, Jean-Pierre Rabès, Alain Carrié, Charles van Heyningen, Valérie Carreau, Michel Farnier, Yee P. Teoh, Mafalda Bourbon, Masa-aki Kawashiri, Atsushi Nohara, Handrean Soran, A. David Marais, Hayato Tada, Marianne Abifadel, Catherine Boileau, Bernard Chanu, Shoji Katsuda, Ichiro Kishimoto, Gilles Lambert, Hisashi Makino, Yoshihiro Miyamoto, Matthieu Pichelin, Kunimasa Yagi, Masakazu Yamagishi, Yassine Zair, Scott Mellis, George D. Yancopoulos, Neil Stahl, Johanna Mendoza, Yunling Du, Sara Hamon, Michel Krempf and Gary D. Swergold

Circulation: Genomic and Precision Medicine. 2015;8:823-831, originally published September 15, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001129

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Finding the Therapeutic Sweet SpotUsing Naturally Occurring Human Variants to Inform Drug Design
John R. Burnett and Robert A. Hegele

Circulation: Genomic and Precision Medicine. 2015;8:637-639, originally published October 20, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001219

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Effect of Bile Acid Sequestrants on the Risk of Cardiovascular EventsCLINICAL PERSPECTIVEA Mendelian Randomization Analysis
Stephanie Ross, Matthew D’Mello, Sonia S. Anand, John Eikelboom, CARDIoGRAMplusC4D Consortium*, Alexandre F.R. Stewart, Nilesh J. Samani, Robert Roberts and Guillaume Paré

Circulation: Genomic and Precision Medicine. 2015;8:618-627, originally published June 4, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000952

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