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Original Article

Genetic Testing in Pediatric Left Ventricular NoncompactionCLINICAL PERSPECTIVE

Erin M. Miller, Robert B. Hinton, Richard Czosek, Angela Lorts, Ashley Parrott, Amy R. Shikany, Richard F. Ittenbach, Stephanie M. Ware
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https://doi.org/10.1161/CIRCGENETICS.117.001735
Circulation: Genomic and Precision Medicine. 2017;10:e001735
Originally published December 6, 2017
Erin M. Miller
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Robert B. Hinton
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Richard Czosek
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Angela Lorts
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Ashley Parrott
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Amy R. Shikany
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Richard F. Ittenbach
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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Stephanie M. Ware
From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
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  • Article
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Jump to

  • Article
    • Abstract
    • Introduction
    • Methods
    • Statistical Analysis
    • Results
    • LVNC Diagnosis
    • Genetic Testing and Results
    • Factors Influencing Cardiomyopathy Gene Panel Testing Yield
    • Discussion
    • Conclusion
    • Acknowledgments
    • Sources of Funding
    • Disclosures
    • Footnotes
    • References
  • Figures & Tables
  • Supplemental Materials
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Article Information

vol. 10 no. 6 e001735
DOI: 
https://doi.org/10.1161/CIRCGENETICS.117.001735
PubMed: 
29212898

Published By: 
American Heart Association, Inc.
Print ISSN: 
1942-325X
Online ISSN: 
1942-3268
History: 
  • Received March 7, 2017
  • Accepted September 20, 2017
  • Originally published December 6, 2017.

Copyright & Usage: 
© 2017 American Heart Association, Inc.

Author Information

  1. Erin M. Miller, MS, LGC,
  2. Robert B. Hinton, MD,
  3. Richard Czosek, MD,
  4. Angela Lorts, MD,
  5. Ashley Parrott, MS, LGC,
  6. Amy R. Shikany, MS, LGC,
  7. Richard F. Ittenbach, PhD and
  8. Stephanie M. Ware, MD, PhD
  1. From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children’s Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).
  1. Correspondence to Erin M. Miller, MS, LGC, Division of Cardiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229. E-mail erin.miller{at}cchmc.org
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Circulation: Genomic and Precision Medicine
December 2017, Volume 10, Issue 6
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    • Abstract
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    • Acknowledgments
    • Sources of Funding
    • Disclosures
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    • References
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    Genetic Testing in Pediatric Left Ventricular NoncompactionCLINICAL PERSPECTIVE
    Erin M. Miller, Robert B. Hinton, Richard Czosek, Angela Lorts, Ashley Parrott, Amy R. Shikany, Richard F. Ittenbach and Stephanie M. Ware
    Circulation: Genomic and Precision Medicine. 2017;10:e001735, originally published December 6, 2017
    https://doi.org/10.1161/CIRCGENETICS.117.001735

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    Genetic Testing in Pediatric Left Ventricular NoncompactionCLINICAL PERSPECTIVE
    Erin M. Miller, Robert B. Hinton, Richard Czosek, Angela Lorts, Ashley Parrott, Amy R. Shikany, Richard F. Ittenbach and Stephanie M. Ware
    Circulation: Genomic and Precision Medicine. 2017;10:e001735, originally published December 6, 2017
    https://doi.org/10.1161/CIRCGENETICS.117.001735
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