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Original Article

Genome-Wide Gene–Potassium Interaction Analyses on Blood PressureCLINICAL PERSPECTIVE

The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity)

Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E. Hixson, Dabeeru C. Rao, Cashell E. Jaquish, Treva K. Rice, Yun Ju Sung, Tanika N. Kelly
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https://doi.org/10.1161/CIRCGENETICS.117.001811
Circulation: Genomic and Precision Medicine. 2017;10:e001811
Originally published December 6, 2017
Changwei Li
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Jiang He
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Jing Chen
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Jinying Zhao
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Dongfeng Gu
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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James E. Hixson
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Dabeeru C. Rao
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Cashell E. Jaquish
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Treva K. Rice
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Yun Ju Sung
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Tanika N. Kelly
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
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Article Information

vol. 10 no. 6 e001811
DOI: 
https://doi.org/10.1161/CIRCGENETICS.117.001811
PubMed: 
29212900

Published By: 
American Heart Association, Inc.
Print ISSN: 
1942-325X
Online ISSN: 
1942-3268
History: 
  • Received May 2, 2017
  • Accepted November 7, 2017
  • Originally published December 6, 2017.

Copyright & Usage: 
© 2017 American Heart Association, Inc.

Author Information

  1. Changwei Li, MD, PhD,
  2. Jiang He, MD, PhD,
  3. Jing Chen, MD,
  4. Jinying Zhao, MD, PhD,
  5. Dongfeng Gu, MD, PhD,
  6. James E. Hixson, PhD,
  7. Dabeeru C. Rao, PhD,
  8. Cashell E. Jaquish, PhD,
  9. Treva K. Rice, PhD,
  10. Yun Ju Sung, PhD and
  11. Tanika N. Kelly, PhD
  1. From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
  1. Correspondence to Changwei Li, MD, PhD, Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, B.S. Miller Hall Room 120, 101 Buck Rd, Athens, GA 30602. E-mail changwei.li{at}uga.edu
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    Genome-Wide Gene–Potassium Interaction Analyses on Blood PressureCLINICAL PERSPECTIVE
    Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E. Hixson, Dabeeru C. Rao, Cashell E. Jaquish, Treva K. Rice, Yun Ju Sung and Tanika N. Kelly
    Circulation: Genomic and Precision Medicine. 2017;10:e001811, originally published December 6, 2017
    https://doi.org/10.1161/CIRCGENETICS.117.001811

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    Genome-Wide Gene–Potassium Interaction Analyses on Blood PressureCLINICAL PERSPECTIVE
    Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E. Hixson, Dabeeru C. Rao, Cashell E. Jaquish, Treva K. Rice, Yun Ju Sung and Tanika N. Kelly
    Circulation: Genomic and Precision Medicine. 2017;10:e001811, originally published December 6, 2017
    https://doi.org/10.1161/CIRCGENETICS.117.001811
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