Letter by van Mil et al Regarding, “Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499”
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To the Editor:
With interest, we read the recent article by Wilson et al1 in Circulation: Cardiovascular Genetics describing the role for miR-499 in dynamic microRNA (miRNA) expression programs during cardiac differentiation of human embryonic stem cells (hESCs). The authors demonstrated that a signature group of miRNAs is present in hESCs, whose expression is significantly altered after cardiomyogenic differentiation. We agree that improved understanding of cardiomyogenic differentiation is important, thereby including miRNA regulation. However, we believe that to understand general miRNA regulation and to interpret in silico prediction analysis, further studies and confirmations are needed, including other available cell sources.
In our previous study,2 we used undifferentiated human cardiac-derived progenitor cells (hCMPCs) and hCMPCs fully differentiated into …