A New Piece in the Cardiac Aging Puzzle
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495:107–110.
Aging is associated with structural remodeling and functional decline in the heart and is an independent risk factor for cardiovascular diseases. Aging results in increased prevalence of cardiac hypertrophy, impaired diastolic function, and compromised myocardial performance. Although the phenotypes of cardiac aging are well characterized, the underlying mechanisms of cardiac aging remain puzzling. Recently, researchers have made important advances in piecing together the cardiac aging puzzle. A study by Loffredo et al1 demonstrated that the blood of young mice can rejuvenate aged mouse hearts and identified growth differentiation factor 11 to be the circulating factor that reverses age-related cardiac hypertrophy. In another study, Flynn et al2 showed that 3-month treatment with rapamycin can reverse cardiac dysfunction in old mice. The 2 studies provide important therapeutic insights in improving myocardial function in the geriatric population.
MicroRNAs (miRNAs) inhibit expression of …