Salt, Immune Function, and the Risk of Autoimmune Diseases
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Autoimmunity has dramatically increased in incidence over recent decades. Studies have shown that a subset of CD4+ T cells, known as interleukin-17 (IL-17)–producing helper T cells (TH17) cells, possess inflammatory properties and promote a variety of autoimmune diseases.1 In the current study, Wu et al2 present evidence that salt induces the differentiation of pathogenic TH17 cells and facilitates the development of autoimmune disease, providing a potential link between increasing salt intake and the rising incidence of autoimmunity.
How Was the Hypothesis Tested?
The authors performed transcriptional profiling of developing TH17 …