Digenic Inheritance of Myocardial Infarction Risk Implicates Dysfunctional Nitric Oxide Signaling
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The systematic identification of rare variants and novel pathways associated with myocardial infarction (MI) has introduced next-generation sequencing technology to large clinical cohorts.1 Although this population-wide approach to uncover the full spectrum of rare variation is promising, it has not replaced the smaller scale sequencing of well-phenotyped families with Mendelian disorders. Erdmann and colleagues2 recently presented a thorough evaluation of one such family in which they identified …