Letter by Brown Regarding Article, “Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome”
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To the Editor:
Although the majority of studies focus on primary prevention, I read with great interest the article by Vaara et al.1 In this article, authors reported the association of a genetic risk score (GRS) composed of 47 susceptibility variants for coronary heart disease (CHD; GRS47) and a GRS composed of 32 variants (GRS32) with secondary CHD events, specifically acute coronary syndrome; a 153-variant GRS (GRS153) was not predictive. This is consistent with the association of a 27-variant GRS with the frequency of primary CHD events and clinical response to statin therapy2 and a 30-variant GRS with the …