Circulation: Genomic and Precision Medicine publishes multiple different types of manuscripts, and authors should pay particular attention to the instructions for each type of article. A brief description of each type follows:
Original Research Articles
Circulation: Genomic and Precision Medicine considers all types of original research articles, including studies conducted in human subjects, laboratory animals, in vitro, and in silico. Articles may include investigations of: clinical genetics as applied to the diagnosis and management of monogenic or oligogenic cardiovascular disorders; the molecular basis of complex cardiovascular disorders, including genome-wide association studies, exome and genome sequencing-based association studies, coding variant association studies, genetic linkage studies, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics; integration of electronic health record data or patient-generated data with any of the aforementioned approaches, including phenome-wide association studies, or with environmental or lifestyle factors; pharmacogenomics; regulation of gene expression; gene therapy and therapeutic genomic editing; systems biology approaches to the diagnosis and management of cardiovascular disorders; novel methods to perform any of the aforementioned studies; and novel applications of precision medicine. Above all, we seek studies with relevance to human cardiovascular biology and disease.
Please note that the editors invite most review articles. However, unsolicited material will be considered for publication upon submission.
- Advances in Molecular Genetics, Genomics, Proteomics, Metabolomics and Systems Biology: Reviews will focus on topics of contemporary interest to the clinician, researchers, including young investigators. Overviews of experimental technologies, diagnostic strategies, and treatment approaches will be included in this series. In addition, the series will also include cutting edge reviews of the molecular basis of disease mechanisms and treatments, and will include molecular cardiology, genetic variation, genomics, transcriptomics, pharmacogenomics, and proteomics, metabolomics and systems biology.
- Methods in Genetics and Clinical Interpretation: Reviews will bring insights from basic investigations into cardiovascular genetics and molecular biology into context for the clinician. This section would include discussion of genetics/genomics and other ‘omics’ tools; use of molecular biology tools such as genome browsers, bioinformatics, expression studies; design of pharmacogenetics studies; etc.
- Controversies in Cardiovascular Genetics: Controversial topics in cardiovascular genetics will be presented in this series. Opposite viewpoints will be presented in tandem, with rebuttal responses by both authors included.
- Correspondence: Letters to the Editor, which pertain directly to an article published in the journal within the preceding 8 weeks, will be considered for publication online. A letter must not exceed 500 words in length and must be limited to three authors and five references. They should not have tables or figures. Authors of the original article cited in the letter will be invited to reply. Letters to the editor should be submitted via the online manuscript submission process as described below.
Please note that all manuscripts must conform to one of the above article types. For additional questions, contact the editorial office.