General Preparation Instructions
All manuscripts must be submitted electronically to https://circgenetics-submit.aha-journals.org. Before proceeding to the online submission site, please prepare your manuscript according to the instructions below. Please also review the journal's Article Types page to ensure that your manuscript meets the criteria set forth for your submission type.
- Maximum Word Length: 7,000 words
- Word Count includes title page, abstract, text, acknowledgments, funding sources, disclosures, references, tables, and figure legends
- Maximum Number of References: 50
- Tables are considered text and must always be part of the manuscript and not uploaded separately. Additionally, the tables must be in an editable format and not images pasted into the manuscript file.
- Maximum Number of Figures and Figure Legends: 8
- Manuscript should be typed double-spaced, including title page, abstract, text, references, tables, and figure legends. Text should only appear on one side of the page. The acceptable format is Word.
- Leave a 1-inch margin on all sides. Do not use justified margins.
- Cite references, tables, and figures in numeric order. For review, it is best to embed (copy/paste) the figures with the corresponding figure legends to the end of the manuscript. If accepted, we will ask for the figures separately in an acceptable figure format. If you are not able to embed the figures then you may provide a single PDF of the figures only or upload the figures in an acceptable review format of Power Point presentation with each figure on separate slides of the presentation.
- Formats NOT supported are as follows: Object Linking and Embedding (OLE), Bitmap (.bmp), PICT (.pict), Excel (.xls), Photoshop (.psd), Canvas (.cnv), CorelDRAW (.cdr), and locked or encrypted PDFs. For publication, see acceptable figure requirements under "Accepted Manuscripts " below.
- Use SI units of measure. A more conventionally used measurement may follow in parentheses. Make all conversions before manuscript submission.
- Please provide sex-specific and/or racial/ethnic-specific data when appropriate, in describing the outcomes of epidemiologic analyses or clinical trials; or specifically state that no sex-based or racial/ethnic-based differences were present.
- Consult the American Medical Association Manual of Style, 9th ed, Baltimore, Md, Williams & Wilkins, 1998, for style.
- Manuscripts must conform to the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" http://www.icmje.org/.
- Assemble the manuscript in this orderClose: Title Page, Abstract, Text, Acknowledgments, Funding Sources, Disclosures, References, Tables, Figure Legends, and Figures.
- The title page (page 1) should contain these elements:
- Full title
- First author's surname and short/running title (not to exceed 50 characters, including spaces)
- Authors' names, academic degrees, and affiliations
Note: Any individuals who need to be cross-referenced in PubMed should be listed either as authors or, for study groups, in the main manuscript file as an Appendix, placed before the Disclosures Statement. If you do not wish to include individuals from a study group as authors or contributors (who are indexed in PubMed), then they should not be listed in the manuscript text file; they should be included in the supplemental material.
- Name and complete address for the corresponding author (include street name and address as well as post office box, and address for reprints if different from correspondence) as well as the telephone number, fax number, and e-mail address.
- The total word count of the manuscript, including the title page, abstract, text, references, tables and figures legends
- The Journal Subject Terms pertaining to the article. Please refer to the subject term list.
Abstract and Key Words
- Do not cite references in the abstract
- Limit use of acronyms and abbreviations. Define at first use acronym or abbreviation in parenthesis.
- Be concise (250 words maximum)
- Use the following headings:
- Background - rationale for study
- Methods and Results - brief presentation of methods and presentation of significant results; please include sample size
- Conclusions - succinct statement of data interpretation
- When applicable, include a fourth heading: "Clinical Trial Registration". Please list the URL, as well as the Unique Identifier, for the publicly accessible website on which the trial is registered.
- Insert three to five Key Words that pertain to the manuscript after the abstract.
- Typical main headings include Methods, Results, and Discussion
- Number pages
- Abbreviations must be defined at first mention
- Please note that the Methods and Results within the manuscript file should be able to stand alone and should provide sufficient information for the reader to understand the basic methods of the study and to review the fundamental findings in a mechanistic way.
- Experimental animals: State the species, strain, number used, and pertinent descriptive characteristics. When describing surgical procedures, identify the preanesthetic and anesthetic agents used and the amounts, concentrations, routes, and frequency of administration of each. Paralytic agents are not considered acceptable substitutes for anesthetics. For other invasive procedures on animals, report the analgesic or tranquilizing drug used. If none were used, provide justification for exclusion.
- Human studies: Indicate that the study was approved by an institutional review committee and that the subjects gave informed consent.
- Drugs and Devices: In the Methods, the complete name and location of the manufacturer must be supplied for all reagents, equipment, and devices used. In all other instances, the generic rather than trademark names of all drugs and devices.
- Independent Data Access and Analysis: The Editors consider it preferable for investigators to have direct access to the primary data in a clinical trial (raw and derived datasets) when reporting results of the trial. Alternatively, an independent party with an academic affiliation who has access to the primary data may serve as the analyst for the investigators. It is recognized that for logistical reasons these options may not be possible in all instances. At a minimum, the authors should have the ability to query any aspect of the data either directly or through an independent analysis. However, the Editors reserve the right to ask for additional information from the corresponding author regarding measures that were taken to minimize bias and verify the integrity of the primary data and any analyses performed.
- Authors should obtain written permission from all individuals who are listed in the "Acknowledgments" section of the manuscript, because readers may infer their endorsement of data and conclusions. The corresponding author must sign the Acknowledgment Section of the Copyright Transfer Agreement, certifying that (1) all persons who have made substantial contributions in the manuscript (eg, data collection, analysis, or writing or editing assistance), but who do not fulfill authorship criteria, are named with their specific contributions in the Acknowledgments section of the manuscript; (2) all persons named in the acknowledgments section have provided the corresponding author with written permission to be named in the manuscript; and (3) if an Acknowledgments section is not included, no other persons have made substantial contributions to this manuscript.
- All sources of support for the research should be listed under this heading.
- All grant funding agency abbreviations should be completely spelled out, with the exception of the NIH.
- All potential conflicts of interest must be stated within the text of the manuscript, under this heading. This pertains to relationships with pharmaceutical companies, biomedical device manufacturers, or other corporations whose products or services are related to the subject matter of the article. Such relationships include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, being on the board of directors, or being publicly associated with the company or its products. Other areas of real or perceived conflict of interest could include receiving honoraria or consulting fees or receiving grants or funds from such corporations or individuals representing such corporations. Please state "None" if no conflicts exist.
- Accuracy of reference data is the responsibility of the author
- Verify all references against original sources
- List 6 authors for each reference followed by "et al. "
- Example reference: 1. Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659-666.
- If you use reference software tools (e.g. EndNote or Reference Manager), they do not always match our style and you may need to manually correct your references.
- Cite references in numeric order according to first mention in the text. In the text, ensure accuracy of spelling and details of publication, i.e., the text citation should match the reference information.
- Personal communications, unpublished observations, and submitted manuscripts are not legitimate references. They must be cited in the text only (not in the reference list) as follows: author name, degree(s) held, unpublished data, year.
- Abstracts may be cited only if they are the sole source and must be identified in the reference as "Abstract."
- References must be from a full length publication in a peer reviewed journal.
- "In press" citations must have been accepted for publication and the name of the journal or book publisher must be included.
- Begin each table on a separate page, double-spaced. Please remember that tables prepared with Excel are not accepted unless embedded within your text document.
- The table number should be Arabic, followed by a period and brief title
- Use same font type as in text
- Supply a brief heading for each column
- Shade table headings at 25% shade for table column heads and 10% shade for internal rows. Internal rows are only shaded if there are subcategories underneath the entry.
- Continue to center table headings, but set columns flush left if they are primarily text.
- Use internal rules in tables.
- When there are multiple entries of data within 1 table cell, set the spacing at 6 pts.
- Indicate footnotes in this order: *, †, ‡, §, | |, #, * *, † †, etc.
- Abbreviations used in the table must be defined in a footnote to the table.
- Figure parts should be clearly labeled. Letters and locants must be uniform in size and style within each figure, and when possible, between figures. (The font size must be 10 point or higher.)
- Avoid headings on the figure. Heading information should appear in the figure legend.
- Line art should not contain hair lines, which are hard to reproduce
- Supply a scale bar with photomicrographs
- Provide double-spaced copy for figure legends on a separate page
- Symbols and abbreviations must be defined in the figure or its legend
- Limit white space between the panel and panel label
- Figures should be sized as close as possible to their final print size. Please note that very few figures qualify for a 2-column format.
- Data Supplements are encouraged as an enhancement to the Methods section. This optional section provides an opportunity to present supporting materials to the manuscript. Please note that all supplements undergo peer review and must be submitted with the original submission of the manuscript.
- Data Supplements can consist of the following:
- Expanded Methods and Results
- Additional Figures
- Additional Tables
- Video Files
- If citations are made in the Supplemental Material, the supplement must contain its own Reference Section, with references numbered sequentially beginning with the number 1. Please try to keep the individual file size to 10 MB or less to facilitate easier downloading for readers.
- Supplemental Material: A PDF of your supplemental material must be provided. The first page of this PDF should include the heading, "SUPPLEMENTAL MATERIAL" followed by your supplemental material. Please note that this single PDF should include all of the supplemental material related to your manuscript, except for the Video or Movie files, but should not include a title page. The supplemental material to be included in this PDF is as follows: Supplemental Methods, Supplemental Tables, Supplemental Figures and Figure Legends, and Supplemental References. Lastly, the legends for the Video files should also be included in this PDF. Please upload this PDF with your submission.
Supplemental Materials Required for Review
- A copy of all submitted manuscripts mentioned in the article must be submitted as part of the review process
- A copy of all manuscripts by the authors, either in preparation or submitted, that potentially overlap with your Circulation: Genomic and Precision Medicine submission must be provided. Please note that failure to include such material is a violation of the journal's Ethical Policy, below.
- A copy of all "in press" articles cited in the Reference section must be supplied for review by the editors and the reviewers