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Volume 2, Issue 2; April, 2009
Editorials
Original Articles
Advances in Genetics, Proteomics, and Metabolomics
Methods in Genetics and Clinical Interpretation
Cardiovascular Genetics: A News Round-Up
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Editorials
Defining the Pathogenicity of DNA Sequence Variation
Carolyn Y. Ho and Calum A. MacRae
Circ Cardiovasc Genet. 2009;2:95-97, doi:10.1161/CIRCGENETICS.109.864793
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Original Articles
Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes
Amitava Banerjee, Louise E. Silver, Carl Heneghan, Sarah J.V. Welch, Linda M. Bull, Ziyah Mehta, Adrian P. Banning, and Peter M. Rothwell
Circ Cardiovasc Genet. 2009;2:98-105; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.806562
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Clinical Perspective
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
Renata I. Dmitrieva, Cruz A. Hinojos, Megan L. Grove, Rebecca J. Bell, Eric Boerwinkle, Myriam Fornage, and Peter A. Doris
Circ Cardiovasc Genet. 2009;2:106-115; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.809509
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Clinical Perspective
Time-Warped Comparison of Gene Expression in Adaptive and Maladaptive Cardiac Hypertrophy
Sean P. Sheehy, Sui Huang, and Kevin Kit Parker
Circ Cardiovasc Genet. 2009;2:116-124; published online before print February 18 2009, doi:10.1161/CIRCGENETICS.108.806935
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Clinical Perspective
Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts
Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C. Bis, Alicja R. Rudnicka, Maryam Kavousi, Ming-Huei Chen, Jens Baumert, Gordon D.O. Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Martin G. Larson, Susana Eyhermendy, Wendy L. McArdle, Thomas Lumley, James S. Pankow, Albert Hofman, Joseph M. Massaro, Fernando Rivadeneira, Melanie Kolz, Kent D. Taylor, Cornelia M. van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S. Aulchenko, Kelly A. Volcik, Andrew D. Johnson, Andre G. Uitterlinden, Geoffrey H. Tofler, Christian Gieger, Wellcome Trust Case Control Consortium, Bruce M. Psaty, David J. Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J. O'Donnell, Jacqueline C. Witteman, David P. Strachan, Nicholas L. Smith, and Aaron R. Folsom
Circ Cardiovasc Genet. 2009;2:125-133, doi:10.1161/CIRCGENETICS.108.825224
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Clinical Perspective
Novel Loci, Including Those Related to Crohn Disease, Psoriasis, and Inflammation, Identified in a Genome-Wide Association Study of Fibrinogen in 17 686 Women: The Womens Genome Health Study
Jacqueline S. Danik, Guillaume Paré, Daniel I. Chasman, Robert Y.L. Zee, David J. Kwiatkowski, Alex Parker, Joseph P. Miletich, and Paul M Ridker
Circ Cardiovasc Genet. 2009;2:134-141; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.825273
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Clinical Perspective
Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population: A Genome-Wide Evaluation of 13 974 Participants in the Womens Genome Health Study
Guillaume Paré, Daniel I. Chasman, Alexander N. Parker, Robert R.Y. Zee, Anders Mälarstig, Udo Seedorf, Rory Collins, Hugh Watkins, Anders Hamsten, Joseph P. Miletich, and Paul M Ridker
Circ Cardiovasc Genet. 2009;2:142-150, doi:10.1161/CIRCGENETICS.108.829804
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Clinical Perspective
COL4A1
Is Associated With Arterial Stiffness by Genome-Wide Association Scan
Kirill V. Tarasov, Serena Sanna, Angelo Scuteri, James B. Strait, Marco Orrù, Afshin Parsa, Ping-I Lin, Andrea Maschio, Sandra Lai, Maria Grazia Piras, Marco Masala, Toshiko Tanaka, Wendy Post, Jeffrey R. O'Connell, David Schlessinger, Antonio Cao, Ramaiah Nagaraja, Braxton D. Mitchell, Gonçalo R. Abecasis, Alan R. Shuldiner, Manuela Uda, Edward G. Lakatta, and Samer S. Najjar
Circ Cardiovasc Genet. 2009;2:151-158; published online before print February 18 2009, doi:10.1161/CIRCGENETICS.108.823245
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Clinical Perspective
Common Genetic Variants on Chromosome 9p21 Confers Risk of Ischemic Stroke: A Large-Scale Genetic Association Study
J. Gustav Smith, Olle Melander, Håkan Lövkvist, Bo Hedblad, Gunnar Engström, Peter Nilsson, Joyce Carlson, Göran Berglund, Bo Norrving, and Arne Lindgren
Circ Cardiovasc Genet. 2009;2:159-164; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.835173
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Clinical Perspective
Association and Functional Analyses of
MEF2A
as a Susceptibility Gene for Premature Myocardial Infarction and Coronary Artery Disease
Ilaria Guella, Valeria Rimoldi, Rosanna Asselta, Diego Ardissino, Maura Francolini, Nicola Martinelli, Domenico Girelli, Flora Peyvandi, Marco Tubaro, Pier Angelica Merlini, Pier Mannuccio Mannucci, and Stefano Duga
Circ Cardiovasc Genet. 2009;2:165-172; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.819326
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Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort
John F. Thompson, Craig L. Hyde, Linda S. Wood, Sara A. Paciga, David A. Hinds, David R. Cox, G. Kees Hovingh, and John J.P. Kastelein
Circ Cardiovasc Genet. 2009;2:173-181; published online before print February 12 2009, doi:10.1161/CIRCGENETICS.108.818062
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Advances in Genetics, Proteomics, and Metabolomics
Multiple Mutations in Genetic Cardiovascular Disease: A Marker of Disease Severity?
Matthew Kelly and Christopher Semsarian
Circ Cardiovasc Genet. 2009;2:182-190, doi:10.1161/CIRCGENETICS.108.836478
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Genetics of Atherothrombotic and Lacunar Stroke
Stéphanie Debette and Sudha Seshadri
Circ Cardiovasc Genet. 2009;2:191-198, doi:10.1161/CIRCGENETICS.108.828319
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Methods in Genetics and Clinical Interpretation
Analysis of Complex Disease Association and Linkage Studies Using the University of California Santa Cruz Genome Browser
Tianyuan Wang and Terrence S. Furey
Circ Cardiovasc Genet. 2009;2:199-204, doi:10.1161/CIRCGENETICS.108.843946
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Cardiovascular Genetics: A News Round-Up
Summary of Recent Articles of Interest
Wolfgang Lieb and Ramachandran S. Vasan
Circ Cardiovasc Genet. 2009;2:205-208, doi:10.1161/CIRCGENETICS.109.859355
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