Table 2.

Clinical Characteristics of the 7 Cases With Significant Polygenic Contribution

IDGRS182AgeSexEventSevBMI, kg/m2WHRSmokHTDbFHxTC, mmol/LLDL, mmol/LHDL, mmol/LTg, mmol/LMedA1c, %
Case 112.4244FSTEMI228.10.92YYNY5.243.200.702.90N6.0
Case 212.2437FSTEMI121.20.93YNNN4.102.561.210.70N5.6
Case 312.0039MNSTEMI228.40.95YNYY4.212.100.932.59Y12.8
Case 411.8538MNSTEMI332.51.05NNNN3.691.910.682.41Y5.3
Case 511.8322MSTEMI123.70.94NNNY6.034.451.140.95N5.4
Case 611.8238MSTEMI127.8NAYYNY4.382.261.251.91Y5.6
Case 711.5738MStable CAD331.50.91YYNY6.223.941.332.08N5.6
  • SI conversion factors: to convert cholesterol to mg/dL, multiply values by 38.61; to convert triglycerides to mg/dL, multiply values by 88.50. A1c indicates glycohemoglobin; BMI, body mass index; CAD, coronary artery disease; Db, diabetes mellitus; F, female; FHx, first-degree family history of CAD (man, <55 y; woman, <65 y); GRS182, genetic risk score based on the presence of 182 independent variants associated with coronary artery disease; HDL, high-density lipoprotein cholesterol; HT, hypertension; ID, identifier; LDL, low-density lipoprotein cholesterol; M, male; Med, cholesterol-lowering medication (statin, fibrate, or ezetimibe) at the time of lipid assessment; N, no; NSTEMI, non–ST-segment–elevation myocardial infarction; Sev, number of major epicardial vessels with ≥50% occlusion at angiography; Smok, active smoking at the time of event; STEMI, ST-segment–elevation myocardial infarction; TC, total cholesterol; Tg, triglycerides; WHR, waist-to-hip ratio; and Y, yes.