Table 3.

Gene-Level Association of Coagulation-Related Genes With CAD/MI and MI in CARDIOGRAMplusC4D 1000 Genomes

Coagulation FactorRelated GenesChromosomeNo. of SNPsGene P Value
CAD/MIMICAD/MIMI
vWFvWF127247170.049*0.22
ThrombinF21172720.240.02*
F2R566650.270.93
F2RL1556550.016*0.13
F2RL251011010.870.78
F2RL31934340.830.80
FibrinogenFGB452520.960.65
Factor VF513693700.420.59
Factor VIIF71373720.070.48
Factor VIIIF8X chromosomen/an/an/an/a
Factor XaF101376740.560.96
Factor XIF1141131120.240.81
Factor XIIIF13A167457390.960.45
tPAPLAT879780.750.46
PAI-1SERPINE1773730.410.65
Thromboxane A synthaseTBXAS177977820.00071*0.000096*
  • CAD/MI indicates coronary artery disease/myocardial infarction; n/a, not available; PAI, plasminogen activator inhibitor; SNP, single-nucleotide polymorphism; tPA, tissue-type plasminogen activator; and vWF, von Willebrand factor.

  • * p value<0.05.