Table 2.

Partial List of Cardiovascular and Related Diseases Modeled With Human Induced Pluripotent Stem Cells or Human Embryonic Stem Cells

Disease ModeledMutated Gene
Dilated cardiomyopathyTTN, TNNT2, LMNA, PLN, DES
Duchenne muscular dystrophyDMD
Barth syndromeTAZ
Hypertrophic cardiomyopathyMYH7
Arrhythmogenic right ventricular dysplasiaPKP2
Left ventricular noncompactionTBX20, GATA4
Long-QT syndrome type 1KCNQ1
Jervell and Lange-Nielsen syndromeKCNQ1
Long-QT syndrome type 2KCNH2
Long-QT syndrome type 3SCN5A
Timothy syndromeCACNA1C
Catecholaminergic polymorphic ventricular tachycardia type 1RYR2
Catecholaminergic polymorphic ventricular tachycardia type 2CASQ2
Brugada syndromeSCN5A
Calcific aortic valveNOTCH1
Williams-Beuren syndromeELN
Familial pulmonary hypertensionBMPR2
Familial hypercholesterolemiaLDLR, PCSK9
Familial hypobetalipoproteinemiaPCSK9
Tangier diseaseABCA1
Maturity-onset diabetes of the young type 2GCK
Insulin resistanceAKT2
Hypoinsulinemic hypoglycemia and hemihypertrophyAKT2