cardiovascular diseases

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Delivering Clinical Grade Sequencing and Genetic Test Interpretation for Cardiovascular Medicine
Andrew R. Harper, Victoria N. Parikh, Rachel L. Goldfeder, Colleen Caleshu and Euan A. Ashley

Circulation: Cardiovascular Genetics. 2017;10:e001221, originally published April 14, 2017
https://doi.org/10.1161/CIRCGENETICS.116.001221

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Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association
Susan Cheng, Svati H. Shah, Elizabeth J. Corwin, Oliver Fiehn, Robert L. Fitzgerald, Robert E. Gerszten, Thomas Illig, Eugene P. Rhee, Pothur R. Srinivas, Thomas J. Wang and Mohit Jain on behalf of the American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council

Circulation: Cardiovascular Genetics. 2017;10:e000032, originally published March 30, 2017
https://doi.org/10.1161/HCG.0000000000000032

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Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association StudiesCLINICAL PERSPECTIVE
Åsa K. Hedman, Michael M. Mendelson, Riccardo E. Marioni, Stefan Gustafsson, Roby Joehanes, Marguerite R. Irvin, Degui Zhi, Johanna K. Sandling, Chen Yao, Chunyu Liu, Liming Liang, Tianxiao Huan, Allan F. McRae, Serkalem Demissie, Sonia Shah, John M. Starr, L. Adrienne Cupples, Panos Deloukas, Timothy D. Spector, Johan Sundström, Ronald M. Krauss, Donna K. Arnett, Ian J. Deary, Lars Lind, Daniel Levy and Erik Ingelsson

Circulation: Cardiovascular Genetics. 2017;10:e001487, originally published February 17, 2017
https://doi.org/10.1161/CIRCGENETICS.116.001487

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Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal AntibodyCLINICAL PERSPECTIVE
Paul N. Hopkins, Joep Defesche, Sigrid W. Fouchier, Eric Bruckert, Gérald Luc, Bertrand Cariou, Barbara Sjouke, Trond P. Leren, Mariko Harada-Shiba, Hiroshi Mabuchi, Jean-Pierre Rabès, Alain Carrié, Charles van Heyningen, Valérie Carreau, Michel Farnier, Yee P. Teoh, Mafalda Bourbon, Masa-aki Kawashiri, Atsushi Nohara, Handrean Soran, A. David Marais, Hayato Tada, Marianne Abifadel, Catherine Boileau, Bernard Chanu, Shoji Katsuda, Ichiro Kishimoto, Gilles Lambert, Hisashi Makino, Yoshihiro Miyamoto, Matthieu Pichelin, Kunimasa Yagi, Masakazu Yamagishi, Yassine Zair, Scott Mellis, George D. Yancopoulos, Neil Stahl, Johanna Mendoza, Yunling Du, Sara Hamon, Michel Krempf and Gary D. Swergold

Circulation: Cardiovascular Genetics. 2015;8:823-831, originally published September 15, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001129

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Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin UsersCLINICAL PERSPECTIVE
Simone A.R. Preil, Lars P. Kristensen, Hans C. Beck, Pia S. Jensen, Patricia S. Nielsen, Torben Steiniche, Marina Bjørling-Poulsen, Martin R. Larsen, Maria L. Hansen and Lars M. Rasmussen

Circulation: Cardiovascular Genetics. 2015;8:727-735, originally published September 14, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001165

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Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein FunctionCLINICAL PERSPECTIVE
Meghan T. Walsh, Jahangir Iqbal, Joby Josekutty, James Soh, Enza Di Leo, Eda Özaydin, Mehmet Gündüz, Patrizia Tarugi and M. Mahmood Hussain

Circulation: Cardiovascular Genetics. 2015;8:677-687, originally published July 29, 2015
https://doi.org/10.1161/CIRCGENETICS.115.001106

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The Influence of Known Genetic Variants on Subclinical Cardiovascular Outcomes in ChildhoodCLINICAL PERSPECTIVEGeneration R Study
Rani V.G. Punwasi, Claire Monnereau, Albert Hofman, Vincent W.V. Jaddoe and Janine F. Felix

Circulation: Cardiovascular Genetics. 2015;8:596-602, originally published April 24, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000915

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Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic PhenotypesCLINICAL PERSPECTIVE
Mohsen Ghanbari, Oscar H. Franco, Hans W.J. de Looper, Albert Hofman, Stefan J. Erkeland and Abbas Dehghan

Circulation: Cardiovascular Genetics. 2015;8:473-486, originally published March 26, 2015
https://doi.org/10.1161/CIRCGENETICS.114.000968

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Basic Concepts and Potential Applications of Genetics and Genomics for Cardiovascular and Stroke CliniciansA Scientific Statement From the American Heart Association
Kiran Musunuru, Kathleen T. Hickey, Sana M. Al-Khatib, Christian Delles, Myriam Fornage, Caroline S. Fox, Lorraine Frazier, Bruce D. Gelb, David M. Herrington, David E. Lanfear and Jonathan Rosand on behalf of the American Heart Association Council on Functional Genomics and Translational Biology, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Hypertension, Council on Lifestyle and Cardiometabolic Health, Council on Quality of Care and Outcomes Research, and Stroke Council

Circulation: Cardiovascular Genetics. 2015;8:216-242, originally published January 5, 2015
https://doi.org/10.1161/HCG.0000000000000020

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Common Low-Density Lipoprotein Receptor p.G116S Variant Has a Large Effect on Plasma Low-Density Lipoprotein Cholesterol in Circumpolar Inuit PopulationsCLINICAL PERSPECTIVE
Joseph B. Dubé, Jian Wang, Henian Cao, Adam D. McIntyre, Christopher T. Johansen, Scarlett E. Hopkins, Randa Stringer, Siyavash Hosseinzadeh, Brooke A. Kennedy, Matthew R. Ban, T. Kue Young, Philip W. Connelly, Eric Dewailly, Peter Bjerregaard, Bert B. Boyer and Robert A. Hegele

Circulation: Cardiovascular Genetics. 2015;8:100-105, originally published November 20, 2014
https://doi.org/10.1161/CIRCGENETICS.114.000646

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